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KMID : 0545120070170071217
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Journal of Microbiology and Biotechnology
2007 Volume.17 No. 7 p.1217 ~ p.1220
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Antifungal Cyclopeptolide from Fungal Saprophytic Antagonist Ulocladium atrum
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Yun Bong-Sik
Kwon Eun-Mi
Kim Jin-Cheol
Yu Seung-Hun
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Abstract
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The saprophytic fungus Ulocladium atrum Preuss is a promising biological control agent for Botrytis cinerea in greenhouse- and field-grown crops. However, despite its known potent antifungal activity, no antifungal substance has yet been reported. In an effort to characterize the antifungal substance from U. atrum, we isolated an antibiotic peptide. Based on extensive spectroscopic analyses, its structure was established as a cyclopeptolide with a high portion of Nmethylated amino acids, and its 1H and 13C chemical shifts were completely assigned based on extensive 1D and 2D NMR experiments. Compound 1 exhibited potent antifungal activity against the plant pathogenic fungus Botrytis cinerea and moderate activity against Alternaria alternate and Magnaporthe grisea
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KEYWORD
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Cyclopeptolide, Ulocladium atrum, antifungal substance, biocontrol agent
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